تفاعل #6945

معادلة التفاعل

4-acetyl-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile

DMF-DMA

→

desired product

4-(3-Dimethylamino-acryloyl)-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe resulting mixture heated
2. 2
   درجة الحرارةat reflux for 18 hours
3. 3
   تركيزThe reaction was concentrated
4. 4
   أخرىthe residue triturated with diethyl ether (20 mL)
5. 5
   ترشيحThe suspension was filtered
6. 6
   غسيلwashed with ether

الإجراء التجريبي

To a solution of 4-acetyl-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile (10 mmol) in acetonitrile (5 mL) was added DMF-DMA (2 mL) and the resulting mixture heated at reflux for 18 hours. The reaction was concentrated and the residue triturated with diethyl ether (20 mL). The suspension was filtered and washed with ether to afford the desired product as a yellow solid.

المصدر