تفاعل #69425

معادلة التفاعل

46

3-Hydroxy-2-(3-(2-((triisopropylsilyl)oxy)ethyl)benzyl)cyclopent-2-enone

i-butanol

→

desired compound

المردود 81.0%

2-(3-(2-Hydroxyethyl)benzyl)-3-isobutoxycyclopent-2-enone

المردود 81.0%

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةto reflux for 12 h
3. 3
   تركيزThe reaction mixture was then concentrated
4. 4
   أخرىthe residue so obtained
5. 5
   أخرىwas purified by silica gel column chromatography

الإجراء التجريبي

A mixture containing 46 (0.294 g, 0.757 mmol), paratoluensolfonic acid (0.005 g), i-butanol (1.0 mL) and benzene (4.0 mL) was heated to reflux for 12 h. The reaction mixture was then concentrated and the residue so obtained was purified by silica gel column chromatography using 5% of methanol in dichloromethane as eluent, obtaining the desired compound. Yield: 81%.

المصدر