تفاعل #694176

معادلة التفاعل

(2S)-2-benzhydryl-oxirane

vinylmagnesium bromide

CuI

(2S)-1,1-diphenyl-pent-4-ene-2-ol

→

(2R)-1,1-diphenyl-pent-4-ene-2-ol

ظروف التفاعل

الإجراء التجريبي

(2S)-2-benzhydryl-oxirane (0.61 g, 2.91 mmol) was reacted with vinylmagnesium bromide (7.26 ml of 1.0M solution in THF, 7.26 mmol) in the presence of CuI (0.055 g, 0.29 mmol) (Procedure A) to yield (2R)-1,1-diphenyl-pent-4-ene-2-ol 0.48 g (70%, [α]D=(+)26, c=1, MeOH). The 1HNMR and 13CNMR were identical with (2S)-1,1-diphenyl-pent-4-ene-2-ol.

المصدر