تفاعل #692983

معادلة التفاعل

4-Nitrophenyl chloroformate

methyl 5-hydroxynicotinate

diisopropylethylamine

→

methyl 5-{[(4-nitrophenoxy)carbonyl]oxy}nicotinate

المردود 76.3%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction liquid
2. 2
   غسيلwas washed with water
3. 3
   تجفيفdried over anhydrous magnesium sulfate
4. 4
   أخرىThe solvent was evaporated
5. 5
   غسيلthe resulting solid was washed with EtOAc/hexane
6. 6
   أخرىdried under reduced pressure

الإجراء التجريبي

4-Nitrophenyl chloroformate (7.0 g) was added to a dichloromethane (100 ml) solution of methyl 5-hydroxynicotinate (5.3 g) and diisopropylethylamine (6.1 ml), followed by stirring at room temperature for 1 hour. The reaction liquid was washed with water, and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the resulting solid was washed with EtOAc/hexane and dried under reduced pressure to obtain methyl 5-{[(4-nitrophenoxy)carbonyl]oxy}nicotinate (8.4 g).

المصدر