تفاعل #691384

معادلة التفاعل

pyridine

acetyl chloride

6-Aminohexanoic acid methyl ester hydrochloride

hydrochloric acid

→

methyl 6-acetylamino-hexanoate

المذيبات

methylene chloride

chloroform

ظروف التفاعل

المعالجة

1. 1
   أخرىthe mixture is separated
2. 2
   غسيلthe organic layer is washed with a saturated brine
3. 3
   تجفيفdried over magnesium sulfate
4. 4
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

6-Aminohexanoic acid methyl ester hydrochloride (5 g) is dissolved in methylene chloride (20 ml) and thereto are added pyridine (4.5 ml) and acetyl chloride (2 ml), and the mixture is stirred at room temperature for 1 hour and 45 minutes. To the reaction solution are added a 1N-hydrochloric acid and chloroform, and the mixture is separated, and the organic layer is washed with a saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure to give methyl 6-acetylamino-hexanoate (5.19 g) as a crude product. MS (m/z): 188 [M+H]+

المصدر