تفاعل #69138

معادلة التفاعل

5-bromo-1H-pyrrolo[2,3-b]pyridine

ammonium hydroxide

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product

المردود 63.0%

1H-pyrrolo[2,3-b]pyridin-5-amine

المردود 63.0%

المذيبات

EtOAc

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةheated in a sealed tube overnight
2. 2
   ترشيحthe insoluble black solid was filtered off
3. 3
   استخلاصThe filtrate was extracted (EtOAc/Water)
4. 4
   غسيلthe organic layer washed with saturated aqueous ammonium chloride
5. 5
   تجفيفThe organics were dried over magnesium sulphate
6. 6
   ترشيحfiltered
7. 7
   أخرىevaporated to dryness

الإجراء التجريبي

5-bromo-1H-pyrrolo[2,3-b]pyridine (6.0 g, 30.45 mmol) in ammonium hydroxide (120 mL) was treated with copper sulphate pentahydrate (1.50 g, 6.09 mmol, 0.2 eq) and heated in a sealed tube overnight. The reaction was diluted with EtOAc and the insoluble black solid was filtered off. The filtrate was extracted (EtOAc/Water) and the organic layer washed with saturated aqueous ammonium chloride, followed by water and brine. The organics were dried over magnesium sulphate, filtered and evaporated to dryness to give the product as a pale brown solid (2.57 g, 63%)

المصدر