تفاعل #69128

معادلة التفاعل

(R)-tert-butyl 1-(4-hydroxyphenyl)ethylcarbamate

→

title compound

المردود 61.0%

(R)-tert-butyl 1-(4-hydroxycyclohexyl)ethylcarbamate

المردود 61.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe rhodium catalyst was filtered off
2. 2
   تركيزthe mother liquors were concentrated in vacuo
3. 3
   أخرىThe residue was purified on silica gel by flash column chromatography

الإجراء التجريبي

(R)-tert-butyl 1-(4-hydroxyphenyl)ethylcarbamate (described in the literature: WO 2007035154 (A1)) (100 mg, 0.4214 mmol) was dissolved in methanol (5 mL). A methanolic (5 mL) solution of rhodium on alumina (10 Wt %, 10 mg) was added. The reaction mixture was place under a hydrogen atmosphere and stir at room temperature for 18 hours. The rhodium catalyst was filtered off and the mother liquors were concentrated in vacuo. The residue was purified on silica gel by flash column chromatography to afford the title compound (62 mg, 61% yield).

المصدر