تفاعل #6907

معادلة التفاعل

2-iodoaniline

dimethylmaleate

triethylamine

→

methyl 2-oxo-1,2-dihydroquinoline-4-carboxylate

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىThe tube was flushed with nitrogen
2. 2
   أخرىsealed
3. 3
   درجة الحرارةThe sealed tube was heated at 100° for 3.5 h
4. 4
   ترشيحthe resulting solids filtered
5. 5
   غسيلwashed with acetonitrile
6. 6
   workup.DISSOLUTIONThe solids were dissolved in chloroform
7. 7
   أخرىthe solvent removed under vacuum
8. 8
   أخرىto provide a solid

الإجراء التجريبي

In a heavy-walled PYREX tube was placed 2-iodoaniline (2.84 g, 13 mmol), dimethylmaleate (2.44 g, 17 mmol), triethylamine (1.4 mL, 10 mmol), palladium diacetate (31 mg, 0.14 mmol) and 6 mL acetonitrile. The tube was flushed with nitrogen and sealed. The sealed tube was heated at 100° for 3.5 h then cooled to r.t. The tube was opened and the resulting solids filtered and washed with acetonitrile. The solids were dissolved in chloroform and the solvent removed under vacuum to provide a solid.

المصدر