تفاعل #690426

معادلة التفاعل

tert-butyl 2-[(4-{[(3,4-dichlorophenyl)amino]carbonyl}piperazin-1-yl)carbonyl]morpholine-4-carboxylate

→

title compound

المردود 97.9%

N-(3,4-Dichlorophenyl)-4-(morpholin-2-ylcarbonyl)piperazine-1-carboxamide

المردود 97.9%

المذيبات

Trifluoroacetic acid dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed under reduced pressure
2. 2
   استخلاصNaOH (aq.) (30 ml) and extracted with ethyl acetate (3×30 ml)
3. 3
   تجفيفThe combined organic layers were dried (MgSO4)
4. 4
   ترشيحfiltered
5. 5
   أخرىevaporated

الإجراء التجريبي

Trifluoroacetic acid/dichloromethane (1:1, 10 ml) was added to tert-butyl 2-[(4-{[(3,4-dichlorophenyl)amino]carbonyl}piperazin-1-yl)carbonyl]morpholine-4-carboxylate (900 mg, impure) followed by stirring for 30 min. The solvent was removed under reduced pressure then taken up in 1M. NaOH (aq.) (30 ml) and extracted with ethyl acetate (3×30 ml). The combined organic layers were dried (MgSO4), filtered and evaporated to form the title compound (700 mg) as a white foam which was used without further purification.

المصدر