تفاعل #690425

معادلة التفاعل

NaBH(OAc)3

N-(3,4-dichlorophenyl)-4-(morpholin-2-ylcarbonyl)piperazine-1-carboxamide

phenacetaldehyde

→

title compound

N-(3,4-Dichlorophenyl)-4-{[4-(2-phenylethyl)morpholin-2-yl]carbonyl}piperazine-1-carboxamide

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was then removed under reduced pressure
2. 2
   workup.DISSOLUTIONdissolved in dichloromethane (40 ml)
3. 3
   أخرىThe organic layer was separated
4. 4
   تجفيفdried (MgSO4)
5. 5
   أخرىevaporated
6. 6
   أخرىPurification by column chromatography 3-7% MeOH

الإجراء التجريبي

To a stirred solution of N-(3,4-dichlorophenyl)-4-(morpholin-2-ylcarbonyl)piperazine-1-carboxamide (350 mg) in dichloromethane (10 ml) under an argon atmosphere was added phenacetaldehyde (0.16 mL) then NaBH(OAc)3 (383 mg) and the reaction was stirred for 3.5 h. The solvent was then removed under reduced pressure and dissolved in dichloromethane (40 ml) and 1M NaOH (20 ml). The organic layer was separated, dried (MgSO4) and evaporated. Purification by column chromatography 3-7% MeOH:DCM afforded the title compound (170 mg) as a white foam

المصدر