تفاعل #690409

معادلة التفاعل

Benzyl 2-[(4-{[(3,4-dichlorophenyl)amino]carbonyl}piperazin-1-yl)methyl]piperazine-1-carboxylate

acetaldehyde

N-(3,4-dichlorophenyl)-4-{[(2S)-4-(2-pyridin-3-ylethyl)morpholin-2-yl]methyl}piperazine-1-carboxamide

→

title product

المردود 18.0%

Benzyl 2-[(4-{[(3,4-dichlorophenyl)amino]carbonyl}piperazin-1-yl)methyl]-4-ethylpiperazine-1-carboxylate

المردود 18.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىexcept that after purification of the residue on a Redisep® silica column
2. 2
   غسيلeluting with ethyl acetate/MeOH (30:70)
3. 3
   أخرىthe solid, after precipitation from CH2Cl2 with isohexane
4. 4
   أخرىwas further purified on an SCX column
5. 5
   غسيلeluting sequentially with ethyl acetate, MeOH and 1% ammonia/MeOH

الإجراء التجريبي

Benzyl 2-[(4-{[(3,4-dichlorophenyl)amino]carbonyl}piperazin-1-yl)methyl]piperazine-1-carboxylate and acetaldehyde were used in a similar manner to N-(3,4-dichlorophenyl)-4-{[(2S)-4-(2-pyridin-3-ylethyl)morpholin-2-yl]methyl}piperazine-1-carboxamide, except that after purification of the residue on a Redisep® silica column, eluting with ethyl acetate/MeOH (30:70), the solid, after precipitation from CH2Cl2 with isohexane, was further purified on an SCX column, eluting sequentially with ethyl acetate, MeOH and 1% ammonia/MeOH to give the title product (20 mg, 18%).

المصدر