تفاعل #690406

معادلة التفاعل

tert-Butyl (2S)-2-({4-[(benzyloxy)carbonyl]piperazin-1-yl}methyl)morpholine-4-carboxylate

→

product

المردود 98.1%

tert-butyl (2S)-2-(piperazin-1-ylmethyl)morpholine-4-carboxylate

المردود 98.1%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe catalyst was then filtered off through a pad of celite and filtrate
2. 2
   أخرىevaporated to dryness
3. 3
   أخرىto give a dark yellow solid
4. 4
   أخرىThis was then purified on Isco™ Companion (120 g column: 10% Methanolic ammonia/DCM)

الإجراء التجريبي

tert-Butyl (2S)-2-({4-[(benzyloxy)carbonyl]piperazin-1-yl}methyl)morpholine-4-carboxylate (11.16 g, 26.6 mmol) was hydrogenated over 10% palladium on carbon (500 mg) in ethanol (100 ml). The catalyst was then filtered off through a pad of celite and filtrate evaporated to dryness to give a dark yellow solid. This was then purified on Isco™ Companion (120 g column: 10% Methanolic ammonia/DCM) to give the product as a pale yellow solid (7.46 g, 26.1 mmol, 98%).

المصدر