تفاعل #689525

ord-d2ff1e1cad3a49b6b083bc46af3bb1f2

معادلة التفاعل

CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)Nc1ccc(Cl)cc1
tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate
→
O=C(Nc1ccc(Cl)cc1)[C@H]1CCC[NH2+]1.[Cl-]
(R)-2-(4-chlorophenylcarbamoyl)pyrrolidinium chloride

المتفاعلات

CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)Nc1ccc(Cl)cc1
tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate

الكواشف

لا شيء

المذيبات

Cl
HCl
C1COCCO1
dioxane

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىThe reaction mixture is evaporated
  2. 2
    أخرىdried

الإجراء التجريبي

4.00 g (12.3 mmol) of tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate are dissolved in 20 ml of 4N HCl in dioxane and left at room temperature for 2 hours. The reaction mixture is evaporated and dried, giving (R)-2-(4-chlorophenylcarbamoyl)pyrrolidinium chloride as a slightly brownish solid; ESI 225.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07906516B2uspto-grants-2011_03