تفاعل #689439

معادلة التفاعل

3-nitro[1,5]naphthyridin-4-amine

[1,5]naphthyridine-3,4-diamine

triethyl orthoacetate

quinoline-3,4-diamine

3-nitroquinolin-4-amine

→

2-methyl-1H-imidazo[4,5-c]quinoline

2-methyl-1H-imidazo[4,5-c][1,5]naphthyridine

ظروف التفاعل

الإجراء التجريبي

In steps (2) and (3) of Reaction Scheme IX, a 3-nitroquinolin-4-amine or 3-nitro[1,5]naphthyridin-4-amine of Formula LXIX is first reduced to a quinoline-3,4-diamine or [1,5]naphthyridine-3,4-diamine of Formula LXX, which is then treated with a carboxylic acid equivalent, such as triethyl orthoacetate, to provide a 2-methyl-1H-imidazo[4,5-c]quinoline or 2-methyl-1H-imidazo[4,5-c][1,5]naphthyridine of Formula LXXI. Steps (2) and (3) of Reaction Scheme IX can be carried out according to the methods described in steps (2) and (3) of Reaction Scheme I.

المصدر