تفاعل #68915

معادلة التفاعل

(S)-5-Oxiranylmethoxy-3,4-dihydro-1H-quinolin-2-one

Z-(1S,6S)-7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene

ethanol

DIPEA

→

title compound

5-[2-Hydroxy-3-(9-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propoxy]-3,4-dihydro-1H-quinolin-2-one

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated from the reaction mixture
2. 2
   أخرىthe residue was purified via flash chromatography (gradient 10% to 100% Ethyl acetate/heptane)

الإجراء التجريبي

(S)-5-Oxiranylmethoxy-3,4-dihydro-1H-quinolin-2-one (25 mg, 0.114 mmol) and Z-(1S,6S)-7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene (30 mg, 0.114 mmol) were placed in a μW tube with ethanol (2 ml), CH2Cl2 (2 mL), DIPEA (100 μL, 0.576 mmol) and heated to 95° C. for 900 sec. The solvent was evaporated from the reaction mixture and the residue was purified via flash chromatography (gradient 10% to 100% Ethyl acetate/heptane) to yield the title compound as a residue.

المصدر