تفاعل #68913

معادلة التفاعل

(S)-1-Methyl-4-oxiranylmethoxy-1H-indole

Z-(1S,6S)-7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene

DIPEA

→

title compound

(S)-1-(1-Methyl-1H-indol-4-yloxy)-3-(9-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propan-2-ol

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated from the reaction mixture
2. 2
   أخرىthe residue was purified via flash chromatography (gradient 30% to 100% ethyl acetate/heptane)

الإجراء التجريبي

(S)-1-Methyl-4-oxiranylmethoxy-1H-indole (50 mg, 0.25 mmol) and Z-(1S,6S)-7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene (50 mg, 0.189 mmol) were placed in a μW tube with ethanol (2 ml), DIPEA (100 μL, 0.576 mmol) and heated to 120° C. for 900 sec. The solvent was evaporated from the reaction mixture and the residue was purified via flash chromatography (gradient 30% to 100% ethyl acetate/heptane) to yield the title compound as a residue.

المصدر