تفاعل #6886

معادلة التفاعل

3-fluoroiodobenzene

4-methyl-1-(2-propynyl)piperidine

→

oil

المردود 56.2%

1-[3-(3-Fluorophenyl)-2-propynyl]-4-methylpiperidine

المردود 56.2%

المذيبات

diethylamine

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةunder reflux for 5 hours
3. 3
   أخرىThe solvent was removed under reduced pressure
4. 4
   غسيلwashed with water
5. 5
   تجفيفThe organic phase was dried over magnesium sulfate
6. 6
   أخرىthe solvent was removed under reduced pressure
7. 7
   workup.DISTILLATIONDistillation of the residue under reduced pressure

الإجراء التجريبي

A mixture of 3-fluoroiodobenzene (8.88 g), 4-methyl-1-(2-propynyl)piperidine (6.80 g), palladium acetate (0.045 g), tri-o-toloylphosphine (0.24 g) and copper(I) iodide (0.1 g) in dry diethylamine (50 ml) was heated under reflux for 5 hours. The solvent was removed under reduced pressure and the residue was taken up in diethyl ether and washed with water. The organic phase was dried over magnesium sulfate and the solvent was removed under reduced pressure. Distillation of the residue under reduced pressure gave an oil (5.20 g) of boiling point 105° C./0.07 mm Hg.

المصدر