تفاعل #6884

معادلة التفاعل

2-iodotoluene

N-(2-propynyl)piperidine

→

oil

المردود 62.3%

1-(3-o-Tolyl-2-propynyl)piperidine

المردود 62.3%

المذيبات

diethylamine

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةunder reflux for 5 hours
3. 3
   أخرىThe solvent was removed under reduced pressure
4. 4
   غسيلwashed with water
5. 5
   تجفيفThe organic phase was dried over magnesium sulfate
6. 6
   تركيزconcentrated completely under reduced pressure
7. 7
   workup.DISTILLATIONDistillation of the residue under reduced pressure

الإجراء التجريبي

A mixture of 2-iodotoluene (6.54 g), N-(2-propynyl)piperidine (3.69 g), dichlorobis(triphenylphosphino)palladium(II) (0.05 g) and copper(I) iodide (0.1 g) in dry diethylamine (50 ml) was heated under reflux for 5 hours. The solvent was removed under reduced pressure and the residue was taken up in diethyl ether and washed with water. The organic phase was dried over magnesium sulfate and concentrated completely under reduced pressure. Distillation of the residue under reduced pressure gave 3.98 g of an oil of boiling point 96–98° C./0.08 mm Hg.

المصدر