تفاعل #687638

معادلة التفاعل

6-chloro-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-9-(trans-4-hydroxycyclohexyl)-7H-purin-8(9H)-one

dihydropyran

p-TsOH

→

desired product

6-chloro-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-9-(trans-4-(tetrahydro-2H-pyran-2-yloxy)cyclohexyl)-7H-purin-8(9H)-one

المذيبات

chloroform THF

ظروف التفاعل

المعالجة

1. 1
   أخرى(LCMS indicative of complete reaction)
2. 2
   تركيزThe reaction mixture was concentrated in vacuo
3. 3
   أخرىthe residue purified by column chromatography on neutral alumina

الإجراء التجريبي

A solution of 6-chloro-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-9-(trans-4-hydroxycyclohexyl)-7H-purin-8(9H)-one (0.8 mmol) and dihydropyran (15 equiv.) in anhydrous chloroform/THF (30 mL/15 mL) containing p-TsOH (0.1 equiv.) was stirred at 50° C. for 1 day (LCMS indicative of complete reaction). The reaction mixture was concentrated in vacuo and the residue purified by column chromatography on neutral alumina to give the desired product. MS (EI) m/z 487.3 (MH)+.

المصدر