تفاعل #68747

معادلة التفاعل

2-(4′-chloro-4-ethylbiphen-3-yl)-3-methoxycyclopent-2-enone

→

2-(4′-chloro-4-ethylbiphen-3-yl)-1,3-cyclopentanedione

المذيبات

acetone

hydrochloric acid

water

hydrochloric acid

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe crude product is extracted with ethyl acetate (3×15 ml)
2. 2
   غسيلwashed with brine (10 ml)
3. 3
   تجفيفdried over anhydrous magnesium sulfate
4. 4
   ترشيحfiltered
5. 5
   أخرىthe filtrate is evaporated to dryness under reduced pressure

الإجراء التجريبي

A solution of 2-(4′-chloro-4-ethylbiphen-3-yl)-3-methoxycyclopent-2-enone (200 mg, 0.61 mmol) in acetone (4 ml) and 2M aqueous hydrochloric acid (4 ml) is heated at 120° C. for 20 minutes under microwave irradiation. The reaction mixture is diluted with water (20 ml) and 2M aqueous hydrochloric acid (10 ml), and the crude product is extracted with ethyl acetate (3×15 ml). The organic extracts are combined, washed with brine (10 ml), dried over anhydrous magnesium sulfate, filtered and the filtrate is evaporated to dryness under reduced pressure to give 2-(4′-chloro-4-ethylbiphen-3-yl)-1,3-cyclopentanedione.

المصدر