تفاعل #6867

معادلة التفاعل

4-Hydroxymethylimidazole hydrochloride

compound xiii

4-Hydroxymethylimidazole hydrochloride

chlorotriphenylmethane

Et3N

→

product

المردود 78.3%

4-Hydroxymethyl-1-triphenylmethyl-imidazole

المردود 78.3%

المذيبات

DMF

DMF

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe resulting mixture was stirred at room temperature for about 23 hours
2. 2
   ترشيحThe product was filtered off
3. 3
   غسيلwashed with cold water (75 ml)
4. 4
   أخرىtriturated with p-dioxane (30 ml)
5. 5
   ترشيحThe product was filtered off
6. 6
   أخرىdried under reduced pressure

الإجراء التجريبي

4-Hydroxymethylimidazole hydrochloride (compound xiii where R2 is H) (2.50 g, 18.6 mmol) and Et3N (2.59 ml, 18.6 mmol) were combined in DMF (30 ml) and stirred at room temperature. A solution of chlorotriphenylmethane (5.19 g, 18.6 mmol) in DMF (25 ml) was added dropwise at room temperature and the resulting mixture was stirred at room temperature for about 23 hours and then poured into ice water (300 ml). The product was filtered off, washed with cold water (75 ml) and triturated with p-dioxane (30 ml). The product was filtered off and dried under reduced pressure to yield product (4.96 g, 78%). NMR (300 MHZ, DMSO-d6, 30° C.) 7.3–7.5 (9H, m), 7.25–7.35 (1H, d), 7.0–7.2 (6H, m), 6.7–6.75 (1H, s), 4.15–4.2 (2H, m).

المصدر