تفاعل #685480

معادلة التفاعل

1-[7-benzyloxy-2-(hydroxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol

pyridine

acetic anhydride

→

[7-benzyloxy-1-(2-hydroxy-2-methylpropyl)-1H-imidazo[4,5-c]quinolin-2-yl]methyl acetate

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىfitted with a calcium chloride drying tube
2. 2
   أخرىA precipitate formed
3. 3
   أخرىwas isolated by filtration
4. 4
   غسيلwashed with deionized water (500 mL)
5. 5
   أخرىdried under vacuum at 50° C.

الإجراء التجريبي

A mixture of 1-[7-benzyloxy-2-(hydroxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol (39.0 g, 0.133 mol), pyridine (390 mL), and acetic anhydride (195 mL) was heated at 35±5° C. for one hour in a reaction flask fitted with a calcium chloride drying tube. The reaction mixture was poured into a mixture of ice (2.5 kg) and deionized water and stirred for approximately 15 minutes. A precipitate formed and was isolated by filtration, washed with deionized water (500 mL), and dried under vacuum at 50° C. to provide 41.8 g of [7-benzyloxy-1-(2-hydroxy-2-methylpropyl)-1H-imidazo[4,5-c]quinolin-2-yl]methyl acetate.

المصدر