تفاعل #685475

معادلة التفاعل

7-benzyloxy-2-(2-methoxyethyl)-1-propyl-1H-imidazo[4,5-c]quinoline

trimethyl orthobutyrate

isobutylamine

methoxypropionyl chloride

fluorobenzene

4-fluorophenyl methyl sulfone

Propylamine

→

7-(4-methanesulfonylphenoxy)-2-(2-methoxyethyl)-1-propyl-1H-imidazo[4,5-c]quinolin-4-amine

ظروف التفاعل

المعالجة

1. 1
   أخرىpurification
2. 2
   أخرىthe product was recrystallized from acetonitrile

الإجراء التجريبي

The general methods described in Parts A-G of Example 1 were used to prepare 7-benzyloxy-2-(2-methoxyethyl)-1-propyl-1H-imidazo[4,5-c]quinoline. Propylamine was used in lieu of isobutylamine in Part E, and methoxypropionyl chloride was used in lieu of trimethyl orthobutyrate in Part G. 7-Benzyloxy-2-(2-methoxyethyl)-1H-propyl-1H-imidazo[4,5-c]quinoline was treated according to the general methods described in Parts A-D of Examples 35-40. In Part B, the fluorobenzene used was 4-fluorophenyl methyl sulfone. Following chromatographic purification, the product was recrystallized from acetonitrile to provide 0.890 g of 7-(4-methanesulfonylphenoxy)-2-(2-methoxyethyl)-1-propyl-1H-imidazo[4,5-c]quinolin-4-amine as dark tan needles, mp 210-212° C.

المصدر