تفاعل #685013

معادلة التفاعل

morpholine

5-fluoro-2-methylbenzenesulfonyl chloride

triethylamine

→

title compound

المردود 81.0%

4-(5-Fluoro-2-methylphenylsulfonyl)morpholine

المردود 81.0%

ظروف التفاعل

الإجراء التجريبي

Following the procedure for Intermediate 1 using 5-fluoro-2-methylbenzenesulfonyl chloride (10.0 g, 48 mmol), triethylamine (13.9 mL, 100 mmol) and morpholine (8.37 g, 96 mmol) gave the title compound as white solid (10.07 g, 81% yield). 1H NMR (300 MHz, CDCl3) δ: 7.58 (1H, dd, J=8.6, 2.7 Hz), 7.27 (1H, dd, J=8.4, 5.1 Hz), 7.15 (1H, td, J=8.1, 2.8 Hz), 3.72-3.68 (4H, m), 3.16-3.13 (4H, m), 2.57 (3H, s). LCMS (M+H) calcd for C11H15FNO3S: 260.07; found: 260.15.

المصدر