تفاعل #684981

معادلة التفاعل

Trifluoroacetic acid

(4-(dodecanoylsulfamoyl)benzyl)carbamic acid tert-butyl ester

→

trifluoroacetic salt

المردود 128.9%

4-Aminomethyl-N-(dodecanoyl)benzenesulfonamide

المردود 128.9%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىwas at room temperature
2. 2
   أخرىThe solvents were removed in vacuo
3. 3
   workup.DISSOLUTIONThe residue was dissolved in dichloromethane (40 ml)
4. 4
   أخرىthe solvent was removed in vacuo

الإجراء التجريبي

Trifluoroacetic acid (25 ml) was at room temperature added to a solution of (4-(dodecanoylsulfamoyl)benzyl)carbamic acid tert-butyl ester (170 mg, 0.40 mmol) in dichloromethane (25 ml). The reaction mixture was stirred for 1 h at room temperature. The solvents were removed in vacuo. The residue was dissolved in dichloromethane (40 ml) and the solvent was removed in vacuo. The latter procedure was repeated once to give 0.19 g of the trifluoroacetic salt of 4-aminomethyl-N-(dodecanoyl)benzenesulfonamide.

المصدر