تفاعل #684975

معادلة التفاعل

ethyl acetate

Potassium carbonate

methyl iodide

compound

2-(4-Bromo-2-fluorobenzyl)-3-pyridinol

→

title compound

المردود 84.4%

2-(4-Bromo-2-fluorobenzyl)-3-methoxypyridine

المردود 84.4%

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   غسيلthe reaction mixture was washed with saturated brine
2. 2
   تركيزconcentrated under reduced pressure
3. 3
   أخرىThe residue was purified by silica gel column chromatography

الإجراء التجريبي

Potassium carbonate (38.7 mg, 0.280 mmol) and methyl iodide (10.5 μl, 0.168 mmol) were added to a solution of the compound of Example B245 (15.8 mg, 0.0560 mmol) in dimethylformamide (1 ml), and this reaction mixture was stirred at room temperature for 2 hours. After ethyl acetate was added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (14.0 mg).

المصدر