تفاعل #684974

معادلة التفاعل

ethyl acetate

Trifluoroacetic acid

compound

2-(4-Bromo-2-fluorobenzyl)-3-(methoxymethoxy)pyridine

sodium hydrogencarbonate

→

title compound

المردود 84.1%

2-(4-Bromo-2-fluorobenzyl)-3-pyridinol

المردود 84.1%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   غسيلThe ethyl acetate layer was washed with saturated brine
3. 3
   تركيزconcentrated under reduced pressure
4. 4
   أخرىThe residue was purified by silica gel column chromatography

الإجراء التجريبي

Trifluoroacetic acid (1 ml) was added to the compound of Example B244 (134 mg, 0.411 mmol) in methylene chloride (4 ml), and this reaction mixture was stirred at room temperature overnight. After neutralizing the mixture with saturated aqueous sodium hydrogencarbonate, ethyl acetate was added. The ethyl acetate layer was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (97.5 mg).

المصدر