تفاعل #684972

معادلة التفاعل

ethyl acetate

Potassium carbonate

methyl iodide

compound

2-(4-Butylbenzyl)-3-pyridinol

→

title compound

المردود 7.2%

2-(4-Butylbenzyl)-3-methoxypyridine

المردود 7.2%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   غسيلthe reaction mixture was washed with saturated brine
2. 2
   تركيزconcentrated under reduced pressure
3. 3
   أخرىThe residue was purified by silica gel column chromatography

الإجراء التجريبي

Potassium carbonate (33.0 mg, 0.239 mmol) and methyl iodide (14.9 μl, 0.239 mmol) were added to a solution of the compound of Example B230 (19.2 mg, 0.0796 mmol) in acetone (1 ml), and this reaction mixture was stirred at room temperature for 3 hours. After ethyl acetate was added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (1.47 mg).

المصدر