تفاعل #684970

معادلة التفاعل

Potassium carbonate

methyl iodide

compound

1-(4-Bromo-2-hydroxyphenyl)-1-butanone

→

title compound

المردود 67.7%

1-(4-Bromo-2-methoxyphenyl)-1-butanone

المردود 67.7%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwhile heating
2. 2
   درجة الحرارةunder reflux for 4 hours
3. 3
   ترشيحThe reaction mixture was filtered through celite, ether
4. 4
   workup.ADDITIONwas added
5. 5
   أخرىto remove insoluble material
6. 6
   ترشيحby filtration
7. 7
   تركيزthe filtrate was concentrated under reduced pressure
8. 8
   أخرىThe residue was purified by silica gel column chromatography

الإجراء التجريبي

Potassium carbonate (9.07 g) and methyl iodide (3.92 ml) were added to a solution of the compound of Example B220 (13.30 g) in acetone (75 ml), and this reaction mixture was stirred while heating under reflux for 4 hours. The reaction mixture was filtered through celite, ether was added to remove insoluble material by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (9.52 g).

المصدر