تفاعل #684969

معادلة التفاعل

Water

ethyl acetate

1-hydroxyisoquinoline

Bromine

→

title compound

المردود 80.1%

4-Bromo-1-isoquinolinol

المردود 80.1%

المذيبات

tetrahydrofuran

acetic acid

ظروف التفاعل

المعالجة

1. 1
   أخرىthe resulting reaction mixture
2. 2
   ترشيحwas filtered
3. 3
   ترشيحthrough filter paper
4. 4
   غسيلThe organic layer was washed with saturated brine
5. 5
   تركيزconcentrated under reduced pressure
6. 6
   أخرىThe residue was recrystallized from ethyl acetate and hexane

الإجراء التجريبي

Bromine (1.78 ml, 34.5 mmol) was added to an ice-cooled solution of 1-hydroxyisoquinoline (5.01 g, 34.5 mmol) in acetic acid (50 ml), and this reaction mixture was stirred at room temperature for 2 hours. Water, ethyl acetate, and tetrahydrofuran were added, and the resulting reaction mixture was filtered through filter paper. The organic layer was washed with saturated brine and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate and hexane to give the title compound (6.19 g).

المصدر