تفاعل #684965

معادلة التفاعل

hydrobromic acid

compound

1-(4-Butylbenzyl)-6-methoxyisoquinoline

→

title compound

المردود 94.6%

1-(4-Butylbenzyl)-6-isoquinolinol

المردود 94.6%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder reflux for 19 hours
2. 2
   تركيزThe mixture was concentrated under reduced pressure, water
3. 3
   workup.ADDITIONwas added
4. 4
   أخرىto precipitate crystals
5. 5
   ترشيحThe obtained crystals were collected by filtration
6. 6
   غسيلwashed with water
7. 7
   أخرىdried

الإجراء التجريبي

A 47% hydrobromic acid solution was added to the compound of Example B146 (82 mg), and the mixture was stirred under reflux for 19 hours. The mixture was concentrated under reduced pressure, water was added, and the resulting mixture was neutralized with sodium carbonate to precipitate crystals. The obtained crystals were collected by filtration, washed with water, and then dried to give the title compound (74 mg).

المصدر