تفاعل #684962

معادلة التفاعل

ammonium formate

compound

1-(3-Methoxyphenyl)-2-nitro-1-ethanol

→

title compound

المردود 72.6%

2-Amino-1-(3-methoxyphenyl)-1-ethanol

المردود 72.6%

المذيبات

tetrahydrofuran

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe catalyst was removed by filtration
2. 2
   workup.ADDITIONthe filtrate was diluted with ether
3. 3
   أخرىprecipitates
4. 4
   أخرىwere removed by filtration
5. 5
   تركيزthe obtained filtrate was concentrated

الإجراء التجريبي

Palladium-carbon (10%, 0.64 g) and ammonium formate (4.8 g) were added to a mixed solution of the compound of Example B142 (3.0 g, 15 mmol) in tetrahydrofuran (43 ml) and methanol (43 ml), and this mixture was stirred at room temperature for 18 hours. The catalyst was removed by filtration, the filtrate was diluted with ether, precipitates were removed by filtration, and the obtained filtrate was concentrated to give the title compound (1.82 g). This compound was used in the following reaction without further purification.

المصدر