تفاعل #684958

معادلة التفاعل

sodium carbonate

2,2-Dimethoxypropane

10-camphorsulfonic acid

dimethylformamide

→

title compound

1-{4-[2-(2,2-Dimethyl-1,3-dioxolan-4-yl)-1-ethynyl]benzyl}-isoquinoline

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe reaction mixture was extracted with ethyl acetate
2. 2
   غسيلwashed with water
3. 3
   تجفيفdried over anhydrous magnesium sulfate
4. 4
   تركيزconcentrated under reduced pressure
5. 5
   أخرىThe residue was purified by silica gel column chromatography

الإجراء التجريبي

2,2-Dimethoxypropane (0.36 ml), 10-camphorsulfonic acid (43 mg), and molecular sieves (4 Å) were added to a solution of the compound of Example B109 (34 mg) in dimethylformamide (2 ml), and this reaction mixture was stirred at 75° C. for 9 hours. After an saturated aqueous sodium carbonate solution was added, the reaction mixture was extracted with ethyl acetate, washed with water, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (14 mg).

المصدر