تفاعل #684952

معادلة التفاعل

sodium hydrogencarbonate

Methanesulfonyl chloride

triethylamine

o-iodobenzyl alcohol

→

title compound

المردود 100.7%

1-(Chloromethyl)-2-iodobenzene

المردود 100.7%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe resulting mixture was extracted with methylene chloride
2. 2
   تجفيفThe methylene chloride layer was dried over anhydrous magnesium sulfate
3. 3
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

Methanesulfonyl chloride (2.0 ml, 29 mmol) and triethylamine (3.6 ml, 26 mmol) were added to a solution of o-iodobenzyl alcohol (5.0 g, 21 mmol) in methylene chloride (50 ml) cooled to 0° C., and the mixture was stirred at that temperature for 19 hours. A 5% aqueous sodium hydrogencarbonate solution was added, and the resulting mixture was extracted with methylene chloride. The methylene chloride layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the title compound (5.34 g).

المصدر