تفاعل #684369

معادلة التفاعل

3-chloro-7-benzyl-7H-indolo[3,2-b][1,5]benzoxazepine-6(5H)-one

phosphorous pentachloride

fumaric acid

N-methyl piperazine

→

7-benzyl-3-chloro-6-(4-methyl-1-piperazinyl)-7H-indolo[3,2-b][1,5]benzoxazepine fumarate

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىwere reacted
2. 2
   أخرىThe product was purified by chromatography on neutral alumina and elution with 3% ethanol in ether
3. 3
   أخرىThe yellow oil thus obtained
4. 4
   أخرىthe salt recrystallized from ethanol for analysis, mp. 217°-8°

الإجراء التجريبي

In the same way as described in example 1, 3-chloro-7-benzyl-7H-indolo[3,2-b][1,5]benzoxazepine-6(5H)-one, phosphorous pentachloride and N-methyl piperazine were reacted. The product was purified by chromatography on neutral alumina and elution with 3% ethanol in ether. The yellow oil thus obtained was reacted with fumaric acid in hot ethanol and the salt recrystallized from ethanol for analysis, mp. 217°-8°.

المصدر