تفاعل #68423
ord-b69f89d9b609410b9caa665553412561
معادلة التفاعل
المتفاعلات
الكواشف
لا شيء
ظروف التفاعل
درجة الحرارة
80°CELSIUS
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1غسيلwashed with brine
- 2تجفيفdried over Na2SO4
- 3تركيزconcentrated in vacuo
- 4أخرىThe residue was purified by chromatography on silica gel (0→50% EtOAc-hexanes)
الإجراء التجريبي
General Procedure Z. To a solution of ethyl1-benzyl-5-fluoro-2-isopropyl-6-nitro-1H-indole-3-carboxylate (Compound 169, 546 mg, 1.54 mmol) in EtOH (10 ml) was added 5 M NaOH (3.1 ml, 15.5 mmol). The reaction was heated at 80° C. for 5 h, diluted with EtOAc, washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by chromatography on silica gel (0→50% EtOAc-hexanes) to yield the title compound as a brown solid.