تفاعل #68413

معادلة التفاعل

HCl

2,6-dichloro-5-fluoronicotinonitrile

→

title compound

(2,6-Dichloro-5-fluoropyridin-3-yl)methanamine

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   أخرىTo a Parr reaction bottle
2. 2
   ترشيحfiltered
3. 3
   تركيزconcentrated
4. 4
   workup.DISSOLUTIONThe crude was dissolved in EtOAc
5. 5
   أخرىthe layers were separated
6. 6
   غسيلThe organic layer was washed with brine
7. 7
   تجفيفdried over Na2SO4
8. 8
   تركيزconcentrated in vacuo

الإجراء التجريبي

To a Parr reaction bottle was added Pd—C (10%, 560 mg, 0.52 mmol), followed by 6 M HCl (50 ml) and a solution of 2,6-dichloro-5-fluoronicotinonitrile (Aldrich, 10.0 g, 52.4 mmol) in MeOH (100 ml). The mixture was placed under 50 psi H2 on a shaker type Parr apparatus for 21 h, filtered and concentrated. The crude was dissolved in EtOAc, basified with aqueous NaOH, and the layers were separated. The organic layer was washed with brine, dried over Na2SO4, and concentrated in vacuo to yield the title compound as crude light yellow oil. Used without further purification.

المصدر