تفاعل #68403
ord-bf784b5b9f7949e294e70ac16f205172
معادلة التفاعل
المتفاعلات
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1غسيلwashed with brine
- 2تجفيفdried over Na2SO4
- 3تركيزconcentrated in vacuo
- 4أخرىThe residue was purified by chromatography on silica gel (0→50% EtOAc-hexanes)
الإجراء التجريبي
A solution of 6-amino-1-benzyl-N-(3,4-difluorobenzyl)-2-isopropyl-1H-indole-3-carboxamide (Compound 125, 20 mg, 0.046 mmol) and ethyl4-bromobutanoate (13 μl, 0.092 mmol) in NMP (1 ml) was heated at 168° C. for 16 h, cooled to room temperature, diluted with EtOAc, washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by chromatography on silica gel (0→50% EtOAc-hexanes) to yield the title compound.