تفاعل #68391

معادلة التفاعل

N-(3,4-difluorobenzyl)-4,4-dimethyl-3-oxopentanamide

Compound 112

N-(3,4-difluorobenzyl)-4,4-dimethyl-3-oxopentanamide

ethyl4-fluoro-3-nitrobenzoate

Compound 113

ethyl4-fluoro-3-nitrobenzoate

K2CO3

→

title compound

Ethyl 4-(1-(3,4-Difluorobenzylamino)-4,4-dimethyl-1,3-dioxopentan-2-yl)-3-nitrobenzoate

المذيبات

EtOAc

DMSO

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with 1 M HCl, H2O, and brine
2. 2
   تجفيفdried over Na2SO4
3. 3
   تركيزconcentrated in vacuo
4. 4
   أخرىThe residue was purified by chromatography on silica gel (0→30% EtOAc-hexanes)

الإجراء التجريبي

To a solution of N-(3,4-difluorobenzyl)-4,4-dimethyl-3-oxopentanamide (Compound 112, 126 mg, 0.47 mmol) and ethyl4-fluoro-3-nitrobenzoate (Compound 113, 100 mg, 0.47 mmol) in DMSO (1 ml) was added K2CO3 (130 mg, 0.94 mmol). The mixture was stirred at room temperature for 16 h, diluted with EtOAc, washed with 1 M HCl, H2O, and brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by chromatography on silica gel (0→30% EtOAc-hexanes) to yield the title compound as a yellow solid.

المصدر