تفاعل #683473

معادلة التفاعل

potassium carbonate

3',4'-dihydrospiro[ cyclohexane-1,2'(1'H)-naphthalen]-4-ylamine hydrochloride

3',4'-Dihydrospiro[cyclohexane- 1,2'(1'H)-naphthalen]-4-ylamine hydrochloride

ethanol

1,5-diiodopentane

→

1-[3',4'-dihydrospiro[cyclohexane-1,2'(1'H)-naphthalen]-4-yl]piperidine

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux temperature for about 18 hours
2. 2
   درجة الحرارةThe mixture after cooling
3. 3
   أخرىthe solid collected on
4. 4
   ترشيحa filter
5. 5
   أخرىrecrystallized from methanol

الإجراء التجريبي

The amine prepared from 1.5 g. of 3',4'-dihydrospiro[ cyclohexane-1,2'(1'H)-naphthalen]-4-ylamine hydrochloride [I(c)] (prepared as in Example 10C), 1.9 g. of 1,5-diiodopentane and 1.6 g. of potassium carbonate in 18 ml. of ethanol is stirred at reflux temperature for about 18 hours. The mixture after cooling is diluted with water, the solid collected on a filter and recrystallized from methanol to give 1-[3',4'-dihydrospiro[cyclohexane-1,2'(1'H)-naphthalen]-4-yl]piperidine [I(c)].

المصدر