تفاعل #68309

معادلة التفاعل

2-(1-benzyl-6-methoxy-1H-indol-2-yl)propan-2-ol

Compound 3

2-(1-benzyl-6-methoxy-1H-indol-2-yl)propan-2-ol

HCl Et2O

→

crude title compound

1-Benzyl-2-isopropyl-6-methoxy-1H-indole

المذيبات

EtOAc

EtOH

ظروف التفاعل

المعالجة

1. 1
   ترشيحwas filtered
2. 2
   workup.ADDITIONTo the filtrate was added NaHCO3 (0.5 g) and H2O (0.5 ml)
3. 3
   ترشيحThis was then filtered
4. 4
   تركيزconcentrated in vacuo

الإجراء التجريبي

To a solution of 2-(1-benzyl-6-methoxy-1H-indol-2-yl)propan-2-ol (Compound 3, 1.05 g, 3.57 mmol) in EtOAc (35 ml) and EtOH (15 ml) was added 10% Pd—C (190 mg, 0.18 mmol) and HCl-Et2O (1.0 M, 1.25 ml, 1.25 mmol). The mixture was stirred under hydrogen gas (atmospheric pressure) for 1 h and was filtered. To the filtrate was added NaHCO3 (0.5 g) and H2O (0.5 ml), followed by Na2SO4 and MgSO4. This was then filtered and concentrated in vacuo to yield the crude title compound as a yellow solid.

المصدر