تفاعل #68008

معادلة التفاعل

4-chloro-7-trifluoromethylquinoline

m-chloroperbenzoic acid

sodium hydrogen carbonate

→

4-chloro-7-trifluoromethylquinoline N-oxide

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   أخرىThe organic layer was separated
3. 3
   استخلاصthe aqueous layer was extracted with chloroform
4. 4
   غسيلthe resultant solution was washed with an aqueous saturated sodium chloride solution
5. 5
   تجفيفdried over anhydrous magnesium sulfate
6. 6
   أخرىthe solvent was removed under reduced pressure

الإجراء التجريبي

To 14 mL of a chloroform solution containing 0.90 g of 4-chloro-7-trifluoromethylquinoline, 1.04 g of m-chloroperbenzoic acid was added, and the mixture was stirred at room temperature for 3.5 hours. The reaction mixture was added with 15 mL of an aqueous saturated sodium hydrogen carbonate solution. The organic layer was separated, and the aqueous layer was extracted with chloroform. The organic layer and the extract were combined, the resultant solution was washed with an aqueous saturated sodium chloride solution, and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain a yellow solid, 4-chloro-7-trifluoromethylquinoline N-oxide.

المصدر