تفاعل #68003

معادلة التفاعل

1-(1,3-dioxolan-2-ylmethyl)-6-isopropylquinolin-2(1H)-one

trifluoroacetic acid

→

(6-isopropyl-2-oxoquinolin-1(2H)-yl)acetaldehyde

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed under reduced pressure, and ethyl acetate
2. 2
   workup.ADDITIONan aqueous saturated sodium hydrogen carbonate solution were added
3. 3
   أخرىThe organic layer was separated
4. 4
   استخلاصthe aqueous layer was extracted with ethyl acetate
5. 5
   غسيلthe resultant solution was washed with an aqueous saturated sodium chloride solution
6. 6
   تجفيفdried over anhydrous magnesium sulfate
7. 7
   أخرىthe solvent was removed under reduced pressure

الإجراء التجريبي

To 0.42 g of 1-(1,3-dioxolan-2-ylmethyl)-6-isopropylquinolin-2(1H)-one, 4 mL of a 90% aqueous trifluoroacetic acid solution was added, and the mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure, and ethyl acetate and an aqueous saturated sodium hydrogen carbonate solution were added thereto. The organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The organic layer and the extract were combined, the resultant solution was washed with an aqueous saturated sodium chloride solution and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain 0.41 g of a pale yellow oily substance, (6-isopropyl-2-oxoquinolin-1(2H)-yl)acetaldehyde.

المصدر