تفاعل #6782

معادلة التفاعل

4-carboxyindole

2-chloro-1-methylpyridinium iodide

4-phenethylpiperazine

ethyldi-isopropylamine

→

(1H-indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride

المردود 100.1%

المذيبات

acetone

N-methylpyrrolidone

NMP

ظروف التفاعل

المعالجة

1. 1
   أخرىthe crude product is obtained
2. 2
   أخرىthe hydrochloride is precipitated
3. 3
   أخرىAfter drying

الإجراء التجريبي

A solution of 2.0 g of 4-carboxyindole and 8.1 g of 2-chloro-1-methylpyridinium iodide in 60 ml of N-methylpyrrolidone (NMP) is treated with a solution of 2.36 g of 4-phenethylpiperazine and 8.2 g of ethyldi-isopropylamine (EDIPA) in 20 ml of NMP and subsequently stirred at room temperature for 3 hours. The mixture is worked up in the customary manner and the crude product is obtained. This is dissolved in acetone and the hydrochloride is precipitated using aqueous hydrochloric acid. After drying, 4.59 g of (1H-indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride, m.p. 289.3°, is obtained.

المصدر