تفاعل #67723

معادلة التفاعل

5-chloromethyl-2,2-difluoro-benzo[1,3]dioxole

sodium cyanide

→

(2,2-difluoro-benzo[1,3]dioxol-5-yl)-acetonitrile

المردود 78.6%

المذيبات

dimethylsulfoxide

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONThe reaction mixture was poured into ice
2. 2
   استخلاصextracted with ethyl acetate (300 mL)
3. 3
   تجفيفThe organic layer was dried over sodium sulfate
4. 4
   أخرىevaporated to dryness

الإجراء التجريبي

A mixture of crude 5-chloromethyl-2,2-difluoro-benzo[1,3]dioxole (4.4 g) and sodium cyanide (1.36 g, 27.8 mmol) in dimethylsulfoxide (50 mL) was stirred at room temperature overnight. The reaction mixture was poured into ice and extracted with ethyl acetate (300 mL). The organic layer was dried over sodium sulfate and evaporated to dryness to give crude (2,2-difluoro-benzo[1,3]dioxol-5-yl)-acetonitrile (3.3 g) which was used directly in the next step.

المصدر