تفاعل #676585

معادلة التفاعل

hydrochloric acid

Ethyl 2-[1-[4-(2,3-dihydrobenzo[b][1,4]dioxin-6-carboxamido)benzyl]-1H-indazol-3-yl]acetate

lithium hydroxide monohydrate

Water

→

solid

المردود 98.6%

2-[1-[4-(2,3-dihydrobenzo[b][1,4]dioxin-6-carboxamido)benzyl]-1H-indazol-3-yl]acetic acid

المردود 98.6%

المذيبات

tetrahydrofuran

—

aqueous solution

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   أخرىIt was reacted at room temperature for 3 h
3. 3
   أخرىA solid precipitated
4. 4
   ترشيحwhich was filtered
5. 5
   أخرىdried

الإجراء التجريبي

Ethyl 2-[1-[4-(2,3-dihydrobenzo[b][1,4]dioxin-6-carboxamido)benzyl]-1H-indazol-3-yl]acetate (260 mg, 0.551 mmol) was dissolved in tetrahydrofuran (20 mL), and in an ice bath, 10 mL aqueous solution dissolving lithium hydroxide monohydrate (70 mg, 1.67 mmol) was added. It was reacted at room temperature for 3 h, and the reaction was monitored to be complete by TLC. Water was added into the system, and adjusted to pH≈3-4 with diluted hydrochloric acid. A solid precipitated, which was filtered and dried to obtain a white solid 241 mg, at a yield of 98.5%.

المصدر