تفاعل #676578

معادلة التفاعل

hydrochloric acid

Ethyl 2-[1-[4-(4-cyanobenzamido)benzyl]-1H-indazol-3-yl]acetate

lithium hydroxide monohydrate

Water

→

solid

المردود 60.9%

2-[1-[4-(4-cyanobenzamido)benzyl]-1H-indazol-3-yl]acetic acid

المردود 60.9%

المذيبات

tetrahydrofuran

—

aqueous solution

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   أخرىIt was reacted at room temperature for 3 h
3. 3
   أخرىA solid precipitated
4. 4
   ترشيحwhich was filtered
5. 5
   أخرىdried
6. 6
   أخرىthe resulting solid was recrystallized from ethyl acetate

الإجراء التجريبي

Ethyl 2-[1-[4-(4-cyanobenzamido)benzyl]-1H-indazol-3-yl]acetate (121 mg, 0.276 mmol) was dissolved in tetrahydrofuran (20 mL), and in an ice bath 10 mL aqueous solution dissolving lithium hydroxide monohydrate (58 mg, 1.38 mmol) was added. It was reacted at room temperature for 3 h, and the reaction was monitored to be complete by TLC. Water was added into the system, and adjusted to pH≈3-4 with diluted hydrochloric acid. A solid precipitated, which was filtered and dried, and the resulting solid was recrystallized from ethyl acetate to obtain a white solid 69 mg, at a yield of 60.9%.

المصدر