تفاعل #676497

ord-0e6b7d98823d4d1ab0247764f0946649

معادلة التفاعل

CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1.Cl
fexofenadine HCl
C(C[*:2])[*:1]
polyethylene
→
CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1
Fexofenadine

المتفاعلات

—
ethylcellulose
CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1.Cl
fexofenadine HCl
C(C[*:2])[*:1]
polyethylene

الكواشف

لا شيء

المذيبات

C1CCCCC1
Cyclohexane

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    درجة الحرارةThe mixture is heated
  2. 2
    درجة الحرارةcooled down
  3. 3
    أخرىMicrocapsules are recovered
  4. 4
    غسيلwashed (one or more times)
  5. 5
    ترشيحfiltered
  6. 6
    أخرىdried over night (about 16 h) in a fume hood
  7. 7
    أخرىat 40° C
  8. 8
    ترشيحThe powder is sieved through a 300 μm

الإجراء التجريبي

Cyclohexane is poured into the microencapsulation reactor. Then, under continuous stirring, fexofenadine HCl, ethylcellulose (EC) and polyethylene are added. The mixture is heated and then cooled down. Microcapsules are recovered, and then washed (one or more times), filtered, and dried over night (about 16 h) in a fume hood or in a hood at 40° C. The powder is sieved through a 300 μm opening sieve.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US09233105B2uspto-grants-2016_01