تفاعل #675856

معادلة التفاعل

diethyl ether

Sodium hydride

1-Adamantanethiol

2-Bromo-6-fluorobenzonitrile

→

title compound

2-(tricyclo[3.3.1.13,7]dec-1-ylsulfanyl)-6-bromo-benzonitrile

المذيبات

dimethyl sulfoxide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe solution was heated to 130° C. for 1 hour
2. 2
   درجة الحرارةThe solution was cooled
3. 3
   غسيلwashed with 1 M aqueous HCl three times
4. 4
   غسيلwashed with brine
5. 5
   تجفيفdried over anhydrous sodium sulfate
6. 6
   ترشيحAfter filtration
7. 7
   أخرىthe solvent was removed under vacuum

الإجراء التجريبي

1-Adamantanethiol (278 mg) was dissolved in dimethyl sulfoxide (10 mL). Sodium hydride (60% in mineral oil, 42 mg) was added, and the solution was stirred at room temperature for 20 minutes. 2-Bromo-6-fluorobenzonitrile (300 mg) was added and the solution was heated to 130° C. for 1 hour. The solution was cooled, added to diethyl ether, washed with 1 M aqueous HCl three times, washed with brine, and dried over anhydrous sodium sulfate. After filtration, the solvent was removed under vacuum to yield the title compound.

المصدر