تفاعل #67559

معادلة التفاعل

Compound 125

Benzyl N-(3-(2-propionyloxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoyl)-L-phenylalanine

→

liquid 126

المردود 94.0%

N-(3-(2-Propionyloxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoyl)-L-phenylalanine

المردود 94.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe catalyst was filtered off
2. 2
   أخرىthe solvent removed under reduced pressure

الإجراء التجريبي

Compound 125 (240 mg, 0.329 mmol) was dissolved in methanol (10 mL) and hydrogenated over Pd/C (60 mg, 30%) under H2 (1 atm) for 3 hr. The catalyst was filtered off and the solvent removed under reduced pressure resulting in the pale-yellow liquid 126 (197 mg, 94%): 1H NMR (400 MHz, CDCl3) δ 1.23 (t, J=7.0, 3H), 1.25 (t, J=7.0, 3H), 1.29-1.40 (m, 18H), 1.41 (s, 3H), 1.43 (s, 3H), 1.54 (s, 3H), 1.56 (s, 3H), 2.27 (d, J=12.9, 1H), 2.42 (d, J=12.8, 1H), 2.54-2.90 (m, 12H), 2.96 (d, J=6.2, 1H), 2.99 (d, J=6.3, 1H), 3.89-4.30 (m, 12H), 4.56-4.78 (m, 2H), 5.72 (d, J=8.5, 1H), 5.85 (d, J=8.9, 1H), 7.07 (dd, J=2.1, 3.6, 2H), 7.09 (dd, J=2.1, 3.6, 2H), 7.13-7.24 (m, 10H), 7.58-7.67 (m, 2H), 7.79-7.87 (m, 2H): 31P (162 MHz, CDCl3) δ 22.28 (d, J=5.3, 1P), 22.37 (d, J=1.9, 1 P), 34.38 (d, J=5.3, 1 P), 34.91 (d, J=1.9, 1 P).

المصدر